Review



gene sequence encoding shp2 residues met1-leu525  (GenScript corporation)

 
  • Logo
  • About
  • News
  • Press Release
  • Team
  • Advisors
  • Partners
  • Contact
  • Bioz Stars
  • Bioz vStars
    • 90
      Buy from Supplier

    Structured Review

    GenScript corporation gene sequence encoding shp2 residues met1-leu525
    IC 50 (half maximal inhibitory concentration) of inhibitors determined by dose–response assay for <t>SHP2.</t> (A) Dose–inhibition curve of SHP099. (B) Dose–inhibition curve of PB17-026-01.
    Gene Sequence Encoding Shp2 Residues Met1 Leu525, supplied by GenScript corporation, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/gene sequence encoding shp2 residues met1-leu525/product/GenScript corporation
    Average 90 stars, based on 1 article reviews
    gene sequence encoding shp2 residues met1-leu525 - by Bioz Stars, 2026-02
    90/100 stars

    Images

    1) Product Images from "Discovery of the SHP2 allosteric inhibitor 2-((3R,4R)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)-5-(2,3-dichlorophenyl)-3-methylpyrrolo[2,1-f][1,2,4] triazin-4(3H)-one"

    Article Title: Discovery of the SHP2 allosteric inhibitor 2-((3R,4R)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)-5-(2,3-dichlorophenyl)-3-methylpyrrolo[2,1-f][1,2,4] triazin-4(3H)-one

    Journal: Journal of Enzyme Inhibition and Medicinal Chemistry

    doi: 10.1080/14756366.2022.2151594

    IC 50 (half maximal inhibitory concentration) of inhibitors determined by dose–response assay for SHP2. (A) Dose–inhibition curve of SHP099. (B) Dose–inhibition curve of PB17-026-01.
    Figure Legend Snippet: IC 50 (half maximal inhibitory concentration) of inhibitors determined by dose–response assay for SHP2. (A) Dose–inhibition curve of SHP099. (B) Dose–inhibition curve of PB17-026-01.

    Techniques Used: Concentration Assay, Inhibition

    Data collection statistics for crystals of PB17-026-01 and SHP2 complexes, PB17-036-01 and SHP2 complexes.
    Figure Legend Snippet: Data collection statistics for crystals of PB17-026-01 and SHP2 complexes, PB17-036-01 and SHP2 complexes.

    Techniques Used:

    (A) Interactions between PB17-026-01 and SHP2. (B) Interactions between PB17-036-01 and SHP2. (C) Superposition of the co-crystal structures of SHP2 in complex of SHP099 (salmon) and PB17-026-01 (yellow). Compared with SHP099, PB17-026-01 lacks the hydrogen bond with E250 but forms hydrogen bond with T253, meanwhile it is hydrogen-bonded with N ε instead of N η of R111. (D) Superposition of the co-crystal structures of SHP2 in the complex of PB17-036-01 (pink) and PB17-026-01 (yellow). The terminal group of PB17-026-01 is hydrogen-bonded with four residues T108, E110, F113, and T253, whereas the terminal group of PB17-036-01 is only hydrogen-bonded with F113 and E249.
    Figure Legend Snippet: (A) Interactions between PB17-026-01 and SHP2. (B) Interactions between PB17-036-01 and SHP2. (C) Superposition of the co-crystal structures of SHP2 in complex of SHP099 (salmon) and PB17-026-01 (yellow). Compared with SHP099, PB17-026-01 lacks the hydrogen bond with E250 but forms hydrogen bond with T253, meanwhile it is hydrogen-bonded with N ε instead of N η of R111. (D) Superposition of the co-crystal structures of SHP2 in the complex of PB17-036-01 (pink) and PB17-026-01 (yellow). The terminal group of PB17-026-01 is hydrogen-bonded with four residues T108, E110, F113, and T253, whereas the terminal group of PB17-036-01 is only hydrogen-bonded with F113 and E249.

    Techniques Used:

    Structure solution and refinement. Values for the outer shell are given in parentheses.
    Figure Legend Snippet: Structure solution and refinement. Values for the outer shell are given in parentheses.

    Techniques Used:



    Similar Products

    gene sequence encoding shp2 residues met1-leu525  (GenScript corporation)
    90
    GenScript corporation gene sequence encoding shp2 residues met1-leu525
    IC 50 (half maximal inhibitory concentration) of inhibitors determined by dose–response assay for <t>SHP2.</t> (A) Dose–inhibition curve of SHP099. (B) Dose–inhibition curve of PB17-026-01.
    Gene Sequence Encoding Shp2 Residues Met1 Leu525, supplied by GenScript corporation, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/gene sequence encoding shp2 residues met1-leu525/product/GenScript corporation
    Average 90 stars, based on 1 article reviews
    gene sequence encoding shp2 residues met1-leu525 - by Bioz Stars, 2026-02
    90/100 stars
    		  Buy from Supplier

    Image Search Results


    IC 50 (half maximal inhibitory concentration) of inhibitors determined by dose–response assay for SHP2. (A) Dose–inhibition curve of SHP099. (B) Dose–inhibition curve of PB17-026-01.

    Journal: Journal of Enzyme Inhibition and Medicinal Chemistry

    Article Title: Discovery of the SHP2 allosteric inhibitor 2-((3R,4R)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)-5-(2,3-dichlorophenyl)-3-methylpyrrolo[2,1-f][1,2,4] triazin-4(3H)-one

    doi: 10.1080/14756366.2022.2151594

    Figure Lengend Snippet: IC 50 (half maximal inhibitory concentration) of inhibitors determined by dose–response assay for SHP2. (A) Dose–inhibition curve of SHP099. (B) Dose–inhibition curve of PB17-026-01.

    Article Snippet: The gene sequence encoding SHP2 residues Met1-Leu525 (UniProt accession code Q06124) was synthesised by GenScript (GenScript.com) with codon optimisation for E. coli expression and inserted into pET-15b containing an N-Terminal 6 × His-tag and a tobacco etch virus (TEV) cleavage site.

    Techniques: Concentration Assay, Inhibition

    Data collection statistics for crystals of PB17-026-01 and SHP2 complexes, PB17-036-01 and SHP2 complexes.

    Journal: Journal of Enzyme Inhibition and Medicinal Chemistry

    Article Title: Discovery of the SHP2 allosteric inhibitor 2-((3R,4R)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)-5-(2,3-dichlorophenyl)-3-methylpyrrolo[2,1-f][1,2,4] triazin-4(3H)-one

    doi: 10.1080/14756366.2022.2151594

    Figure Lengend Snippet: Data collection statistics for crystals of PB17-026-01 and SHP2 complexes, PB17-036-01 and SHP2 complexes.

    Article Snippet: The gene sequence encoding SHP2 residues Met1-Leu525 (UniProt accession code Q06124) was synthesised by GenScript (GenScript.com) with codon optimisation for E. coli expression and inserted into pET-15b containing an N-Terminal 6 × His-tag and a tobacco etch virus (TEV) cleavage site.

    Techniques:

    (A) Interactions between PB17-026-01 and SHP2. (B) Interactions between PB17-036-01 and SHP2. (C) Superposition of the co-crystal structures of SHP2 in complex of SHP099 (salmon) and PB17-026-01 (yellow). Compared with SHP099, PB17-026-01 lacks the hydrogen bond with E250 but forms hydrogen bond with T253, meanwhile it is hydrogen-bonded with N ε instead of N η of R111. (D) Superposition of the co-crystal structures of SHP2 in the complex of PB17-036-01 (pink) and PB17-026-01 (yellow). The terminal group of PB17-026-01 is hydrogen-bonded with four residues T108, E110, F113, and T253, whereas the terminal group of PB17-036-01 is only hydrogen-bonded with F113 and E249.

    Journal: Journal of Enzyme Inhibition and Medicinal Chemistry

    Article Title: Discovery of the SHP2 allosteric inhibitor 2-((3R,4R)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)-5-(2,3-dichlorophenyl)-3-methylpyrrolo[2,1-f][1,2,4] triazin-4(3H)-one

    doi: 10.1080/14756366.2022.2151594

    Figure Lengend Snippet: (A) Interactions between PB17-026-01 and SHP2. (B) Interactions between PB17-036-01 and SHP2. (C) Superposition of the co-crystal structures of SHP2 in complex of SHP099 (salmon) and PB17-026-01 (yellow). Compared with SHP099, PB17-026-01 lacks the hydrogen bond with E250 but forms hydrogen bond with T253, meanwhile it is hydrogen-bonded with N ε instead of N η of R111. (D) Superposition of the co-crystal structures of SHP2 in the complex of PB17-036-01 (pink) and PB17-026-01 (yellow). The terminal group of PB17-026-01 is hydrogen-bonded with four residues T108, E110, F113, and T253, whereas the terminal group of PB17-036-01 is only hydrogen-bonded with F113 and E249.

    Article Snippet: The gene sequence encoding SHP2 residues Met1-Leu525 (UniProt accession code Q06124) was synthesised by GenScript (GenScript.com) with codon optimisation for E. coli expression and inserted into pET-15b containing an N-Terminal 6 × His-tag and a tobacco etch virus (TEV) cleavage site.

    Techniques:

    Structure solution and refinement. Values for the outer shell are given in parentheses.

    Journal: Journal of Enzyme Inhibition and Medicinal Chemistry

    Article Title: Discovery of the SHP2 allosteric inhibitor 2-((3R,4R)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)-5-(2,3-dichlorophenyl)-3-methylpyrrolo[2,1-f][1,2,4] triazin-4(3H)-one

    doi: 10.1080/14756366.2022.2151594

    Figure Lengend Snippet: Structure solution and refinement. Values for the outer shell are given in parentheses.

    Article Snippet: The gene sequence encoding SHP2 residues Met1-Leu525 (UniProt accession code Q06124) was synthesised by GenScript (GenScript.com) with codon optimisation for E. coli expression and inserted into pET-15b containing an N-Terminal 6 × His-tag and a tobacco etch virus (TEV) cleavage site.

    Techniques: